Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | 5-Chloro-2,3-difluoropyridine | HCID 2783248 | — |
| Catalyst | Copper | HCID 23978 | — |
| Product | HCID 18466516 | HCID 18466516 | — |
Reaction Steps
Starting from 93 g (0.508 mol) of 2,3-difluoro-5-chloropyridine, 58.8 g (0.5276 mol) of 98.7% pure thiophenol and 3.2 mg (0.01 mol %) of copper powder which were stirred in a pressure apparatus at 185° C. for 1.5 h and worked up by the method of Example 1, 121.5 g (99.9% of theory) of the title compound were obtained as a colorless oil. 1H-NMR (ppm, d6DMSO) 8.35 (s/1H), 8.05 (d/1H), 7.4-7.6 (m/5H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06191280B1 |
|---|
| Source dataset | uspto-grants-2001_02 |
|---|
| ORD ID | ord-2de4c54c9f25433ebd635abf6d4e93d6 |
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| Source note | uspto-grants-2001_02 |
|---|
