Sulfuric Acid → HCID 21257363, compound

HRID 636076Notes

Reaction equation

HRID 636076 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12](=[O:19])[CH2:13][C:14](=O)[CH2:15][CH2:16][CH3:17])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.OS(O)(=O)=O>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[C:5]2[C:4]=1[C:14]([CH2:15][CH2:16][CH3:17])=[CH:13][C:12](=[O:19])[NH:11]2

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 85782707HCID 85782707, compound

Product 1

HCID 21257363HCID 21257363, compoundYield 90%

Procedure

Compound 10 (19 g, 71.69 mmol) was treated with Conc. H2SO4 (48 mL, 901 mmol) for 30 min. as described for II after usual work up afforded 5,7-dimethoxy-4-propyl-1,2-dihydro-2-quinolinone (12,159) in 90% yield as a white solid. M.P. 193-196° C.

Sources & evidence

ORD record
ord-b24a8f07793d47fba89a6c931d03baab
Source dataset
uspto-grants-2001_02
Patent number
US06191279B1

Reaction notes

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