2-Thiopheneacetic acid → 2-[(2-Thienyl)acetamido]butyric acid isobutyl ester

HRID 636115Notes

Reaction equation

HRID 636115 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([OH:9])=O.[NH2:10][CH:11]([CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[O:13]>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]([NH:10][C:7](=[O:9])[CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH2:19][CH3:20])[CH:16]([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 159702-Thiopheneacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 544436822-[(2-Thienyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I′ above and using 2-thiopheneacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-cc33725ff17f48298c517e0447818dd2
Source dataset
uspto-grants-2001_02
Patent number
US06191166B1

Reaction notes

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