HCID 69910017, compound → HCID 54295887, compound

HRID 636282Notes

Reaction equation

HRID 636282 reaction equation
[NH2:1][C@@:2]1([N:28]2[CH2:36][C:34](C(OC)C3C=CC=CC=3)([CH3:35])[C:32](=[O:33])[NH:31][C:29]2=[O:30])[O:18][C@H:6]([CH:7](C(OC)C2C=CC=CC=2)[OH:8])[C@@:4](C(OC)C2C=CC=CC=2)([OH:5])[CH2:3]1>[Pd].C(O)C>[NH2:1][C@@:2]1([N:28]2[CH:36]=[C:34]([CH3:35])[C:32](=[O:33])[NH:31][C:29]2=[O:30])[O:18][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[CH2:3]1

Participants

4

Reactant 1

HCID 69910017HCID 69910017, compound

Product 1

HCID 54295887HCID 54295887, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 1′-amino-3′, 5′, 5-tris(methoxybenzyl) thymidine and 10% palladium on charcoal in ethanol is shaken in a hydrogenation apparatus under hydrogen pressure of 50 psi for 24 h. The solid is filtered and the filtrate concentrated. The crude is purified by recrystallization.

Workup

  1. filtrationThe solid is filtered
  2. concentrationthe filtrate concentrated
  3. customThe crude is purified by recrystallization

Sources & evidence

ORD record
ord-2c6354398c1e45b9ac22f1f482daa0b8
Source dataset
uspto-grants-2001_02
Patent number
US06191266B1

Reaction notes

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