反应详情

10 ml of a 50% solution of NH3 in MeOH was added to a solution of 0.50 g (1.3 mmol) of 3-benzenesulphonyl-7-chloro-5-methoxymethyl-2-methylsulphanyl-pyrazolo[1,5-a]-pyrimidine in 10 ml of DMF and stirred at RT for 2 hrs. The reaction solution was evaporated and the residue was partitioned between 2N NaOH and CH2Cl2. The aqueous phase was extracted three times with CH2Cl2, and the combined organic phases were dried (MgSO4), filtered and evaporated. Subsequent chromatography (SiO2, CH2Cl2/MeOH 10:1) and crystallization from EtOH yielded 0.38 g (80%) of 3-benzenesulphonyl-5-methoxymethyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidin-7-ylamine as colorless crystals, m.p.>230°.

1. customThe reaction solution was evaporated
2. customthe residue was partitioned between 2N NaOH and CH2Cl2
3. extractionThe aqueous phase was extracted three times with CH2Cl2
4. dry with materialthe combined organic phases were dried (MgSO4)
5. filtrationfiltered
6. customevaporated
7. customSubsequent chromatography (SiO2, CH2Cl2/MeOH 10:1) and crystallization from EtOH