Acetic Anhydride → HCID 10797410, compound

HRID 636488Notes

Reaction equation

HRID 636488 reaction equation
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[CH2:4][OH:5].[C:11](OC(=O)C)(=[O:13])[CH3:12]>CN(C)C1C=CN=CC=1>[C:11]([O:5][CH2:4][C:3]1[C:6]([CH3:10])=[CH:7][CH:8]=[CH:9][C:2]=1[CH3:1])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 186748(2,6-Dimethylphenyl)methanol

Product 1

HCID 10797410HCID 10797410, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Conditions

Temperature
70 °C

Procedure

To a mixture of 2,6-dimethylbenzyl alcohol (17.1 g) and acetic anhydride (14.2 ml) was added 4-dimethylaminopyridine (17 mg), and the mixture was stirred at 70° C. for 5 hours. After cooling, the mixture was concentrated in vacuo, and ethyl acetate was added to the residue. The solution was washed with water, dried over magnesium sulfate and evaporated in vacuo to give 2,6-dimethylbenzyl acetate (22.5 g) as colorless oil.

Workup

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated in vacuo, and ethyl acetate
  3. additionwas added to the residue
  4. washThe solution was washed with water
  5. dry with materialdried over magnesium sulfate
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-9015aca61a52430181bef1f1828361c1
Source dataset
uspto-grants-2001_02
Patent number
US06194396B1

Reaction notes

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