反应详情

3.50 g (20 mmol) of 2,3-dichlorobenzaldehyde, 2.80 g (20 mmol) of dimedone and 2.86 g (20 mmol) of isopropyl 3-aminocrotonate are dissolved in 100 ml of isopropanol and stirred under reflux for 5 h. The product precipitates. The mixture is treated with 50 ml of water and cooled to RT. The product is filtered off with suction and washed successively with isopropanol, ethanol and ether. 6.6 g (78% of theory) of the title compound are obtained.

1. temperatureunder reflux for 5 h
2. customThe product precipitates
3. additionThe mixture is treated with 50 ml of water
4. filtrationThe product is filtered off with suction
5. washwashed successively with isopropanol, ethanol and ether