反应详情

To a solution of methyl 4-(methylamino)benzoate (2.0 g, 12.1 mmol) in THF (30 mL) was added LAH (6.1 mL, 2.4 M in THF, 14.5 mmol) at 0° C. The reaction was stirred at r.t. for 2 h. The reaction was quenched with EtOAc (50 mL) and water (2 mL). The mixture was dried (Na2SO4) and concentrated. Purification by silica gel chromatography (PE:EtOAc=3:1) gave 1.0 g (60%) of the title compound as a yellow oil. [M+H] Calc'd for C8H11NO, 138. Found 138.

1. customThe reaction was quenched with EtOAc (50 mL) and water (2 mL)
2. dry with materialThe mixture was dried (Na2SO4)
3. concentrationconcentrated
4. customPurification by silica gel chromatography (PE:EtOAc=3:1)