Ethyl piperidine-2-carboxylate → HCID 70235600, compound

HRID 636562Notes

Reaction equation

HRID 636562 reaction equation
[NH:1]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:2]1[C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl[C:13]([C:15]1[S:19][CH:18]=[N:17][CH:16]=1)=[O:14]>>[S:19]1[C:15]([C:13]([N:1]2[CH2:11][CH2:10][CH2:9][CH2:8][CH:2]2[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[O:14])=[CH:16][N:17]=[CH:18]1

Participants

3

Reactant 2

HCID 27517Ethyl piperidine-2-carboxylateHCID 224581411,3-Thiazole-5-carbonyl chloride

Product 1

HCID 70235600HCID 70235600, compound

Procedure

Ethyl N-(5-thiazolylcarbonyl)pipecolinate is prepared as in Example 1, from 4.4 g of ethyl pipecolinate and 5.25 g of 5-chloroformylthiazole. 7.7 g of ethyl N8(5-thiazolylcarbonyl)pipecolinate are thus obtained in the form of brown oil. (Rf=0.51; thin layer chromatography on silica gel; eluent: 55/45 dichloromethane/ethyl acetate).

Sources & evidence

ORD record
ord-5bbf1ed3df1c44bfbe7c2709a0c6d8d9
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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