HCID 21255118, compound → HCID 21255199, compound

HRID 636567Notes

Reaction equation

HRID 636567 reaction equation
[Cl:1][C:2]1[C:3]([C:17]([O:19]C)=[O:18])=[C:4]2[N:9]([C:10]=1[C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][CH2:7][CH2:6][CH2:5]2>ClCCl.CO>[Cl:1][C:2]1[C:3]([C:17]([OH:19])=[O:18])=[C:4]2[N:9]([C:10]=1[C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][CH2:7][CH2:6][CH2:5]2

Participants

3

Reactant 1

HCID 21255118HCID 21255118, compound

Product 1

HCID 21255199HCID 21255199, compoundYield 84.1%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

2-Chloro-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylic acid is prepared as in Example 44, from 0.9 g of methyl 2-chloro-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylate. 0.72 g of 2-chloro-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylic acid are thus obtained in the form of a white powder (Rf=0.43; thin layer chromatography on silica gel; eluent: 9/1 dichloromethane/methanol).

Sources & evidence

ORD record
ord-1ee9ddcdedb646b28741c5a468906876
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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