Diisopropylethylamine → N-(4-cyclopropylphenyl)-2-methoxyacetamide

HRID 63657Notes

Reaction equation

HRID 63657 reaction equation
[CH3:1][O:2][CH2:3][C:4](Cl)=[O:5].[CH:7]1([C:10]2[CH:16]=[CH:15][C:13]([NH2:14])=[CH:12][CH:11]=2)[CH2:9][CH2:8]1.CCN(C(C)C)C(C)C>C(Cl)Cl>[CH:7]1([C:10]2[CH:16]=[CH:15][C:13]([NH:14][C:4](=[O:5])[CH2:3][O:2][CH3:1])=[CH:12][CH:11]=2)[CH2:9][CH2:8]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 96623Methoxyacetyl chlorideHCID 122539274-Cyclopropylaniline

Product 1

HCID 118597819N-(4-cyclopropylphenyl)-2-methoxyacetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methoxyacetyl chloride (0.55 mL, 6.0 mmol) was added to a solution of 4-cyclopropylaniline (800 mg, 6.0 mmol) and DIEA (1.05 mL, 6.0 mmol) in DCM, and the reaction was stirred at r.t. for 2 h. The reaction was washed with brine, dried (MgSO4), and concentrated to give crude N-(4-cyclopropylphenyl)-2-methoxyacetamide.

Workup

  1. washThe reaction was washed with brine
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-09f64ff50e344b66b800deee7ea5a30d
Source dataset
uspto-grants-2016_09
Patent number
US09447046B2

Reaction notes

Loading…