Sodium Hydroxide → 2-Bromo-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylic acid

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Reaction Steps

1 cm3 of 5N sodium hydroxide is added with stirring to a solution of 0.34 g of methyl 2-bromo-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylate in methanol at 20° C. The orangy solution is heated to reflux for 15 hours. The solvent is then evaporated off at reduced pressure (2.7 kPa) at a temperature close to 40° C. The residue is taken up with 10 cm3 of water and acidified to pH˜3 with 0.2 cm3 of 12N hydrochloric acid and 0.5 cm3 of 1N acetic acid. The precipitate is filtered off, washed with water and then dried in air. 0.29 g of 2-bromo-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylic acid are thus obtained in the form of a cream powder which melts at >260° C., with decomposition.

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