HCID 22012136, compound → HCID 21255146, compound

HRID 636575Notes

Reaction equation

HRID 636575 reaction equation
[C:1]([C:4]1[C:5]([Cl:20])=[C:6]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[N:7]2[C:12]=1[CH:11]=[C:10](Cl)[CH2:9][CH2:8]2)(=[O:3])[CH3:2]>[Pd]>[C:1]([C:4]1[C:5]([Cl:20])=[C:6]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[N:7]2[C:12]=1[CH2:11][CH2:10][CH2:9][CH2:8]2)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 22012136HCID 22012136, compound

Product 1

HCID 21255146HCID 21255146, compoundYield 3.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1-Acetyl-2-chloro-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine is prepared as described in Example 39, from 1.7 g of 1-acetyl-2,7-dichloro-3-(3-pyridyl)-5,6-dihydroindolizine and from 0.09 g of 10% palladium on charcoal. 0.05 g of 1-acetyl-2-chloro-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine are thus obtained in the form of whitish crystalline solid melting at 115° C.

Workup

  1. custom1-Acetyl-2-chloro-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine is prepared

Sources & evidence

ORD record
ord-55f2b2144f9540b9af75cd4195452d90
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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