Chlorosulfonyl isocyanate → HCID 21255203, compound

HRID 636577Notes

Reaction equation

HRID 636577 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:15]3[C:10]([CH2:11][CH2:12][CH2:13][CH2:14]3)=[C:9]([C:16]#[N:17])[CH:8]=2)[CH:2]=1.[N:18]1C=CC=C(C2N3C(CCCC3)=CC=2C#N)[CH:19]=1.S(Cl)(N=C=O)(=O)=O>>[C:19]([C:8]1[C:9]([C:16]#[N:17])=[C:10]2[N:15]([C:7]=1[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[CH2:14][CH2:13][CH2:12][CH2:11]2)#[N:18]

Participants

4

Reactant 3

HCID 70918Chlorosulfonyl isocyanateHCID 11831061HCID 11831061, compoundHCID 21255210HCID 21255210, compound

Product 1

HCID 21255203HCID 21255203, compound

Procedure

2-Cyano-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile is prepared according to the same method described in Example 15, from 19.3 g of a mixture of approximately 35 mol % of 3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile and 65 mol % of 3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-2-carbonitrile and from 36.6 g of sulphonyl isocyanate chloride. 2.8 g of 2-cyano-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile are thus obtained in the form of a white solid melting at 178° C.

Workup

  1. custom2-Cyano-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile is prepared

Sources & evidence

ORD record
ord-d2b09054cb00400f81ac069eba3e39ae
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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