Chlorosulfonyl isocyanate → HCID 21255203, compound

Participants

Reaction Steps

2-Cyano-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile is prepared according to the same method described in Example 15, from 19.3 g of a mixture of approximately 35 mol % of 3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile and 65 mol % of 3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-2-carbonitrile and from 36.6 g of sulphonyl isocyanate chloride. 2.8 g of 2-cyano-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile are thus obtained in the form of a white solid melting at 178° C.

Provenance & Evidence