反应详情

To a solution of 2-methyl-5-methoxy-pyridine (2.93 g, 24 mmol) in DCM (100 mL) was added sodium sulphate (5 g, 35 mmol), followed by m-chloro-peroxy-benzoic acid (10 g, 58 mmol), and mixture was stirred at room temperature for ˜48 hours. The reaction mixture was filtered, and the white solid was washed with DCM. The filtrate was concentrated and purified by normal phase chromatography eluting with a gradient of 1:1 EtOAc/heptane to EtOAc to give 2-methyl-5-methoxy-pyridine-N-oxide (2.41 g, 72%).

1. filtrationThe reaction mixture was filtered
2. washthe white solid was washed with DCM
3. concentrationThe filtrate was concentrated
4. custompurified by normal phase chromatography
5. washeluting with a gradient of 1:1 EtOAc/heptane to EtOAc