Trifluoroacetic acid → HCID 178427568, compound

HRID 636675Notes

Reaction equation

HRID 636675 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:20]([OH:22])=[O:21])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:19])[NH:8][S:9]([C:12]1[CH:18]=[CH:17][C:15]([CH3:16])=[CH:14][CH:13]=1)(=[O:11])=[O:10].[S:30]1[CH:34]=[CH:33][N:32]=[CH:31]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:1][C@H:2]([C:20]([OH:22])=[O:21])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:19])[NH:8][S:9]([C:12]1[CH:18]=[CH:17][C:15]([CH3:16])=[CH:14][CH:13]=1)(=[O:11])=[O:10].[S:30]1[CH:34]=[CH:33][N:32]=[CH:31]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178427600HCID 178427600, compound

Product 1

HCID 178427568HCID 178427568, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of Boc-Arg(Tos)-Thiazole (300 mg, 0.6 mmol) in CH2Cl2 (10 mL) at 0° C. is added TFA (10 mL). The solution is stirred at 0° C. for 2 h. The solvent and excess TFA are evaporated to an oily residue which is used directly without further purification.

Workup

  1. customThe solvent and excess TFA are evaporated to an oily residue which
  2. customis used directly without further purification

Sources & evidence

ORD record
ord-48cffc06f1424eba99b1c966e7b3cfe0
Source dataset
uspto-grants-2001_02
Patent number
US06194435B1

Reaction notes

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