1-(2-Iodoethyl)-4-nitrobenzene → 2-Amino-3-(4-chloro-benzoyl)-6-[4-nitro-(2-phenyleth-1-yl)]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

HRID 636697Notes

Reaction equation

HRID 636697 reaction equation
[NH2:1][C:2]1[S:10][C:5]2[CH2:6][NH:7][CH2:8][CH2:9][C:4]=2[C:3]=1[C:11](=[O:19])[C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1.[N+:20]([C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH2:30]I)=[CH:25][CH:24]=1)([O-:22])=[O:21]>>[NH2:1][C:2]1[S:10][C:5]2[CH2:6][N:7]([CH2:30][CH2:29][C:26]3[CH:25]=[CH:24][C:23]([N+:20]([O-:22])=[O:21])=[CH:28][CH:27]=3)[CH2:8][CH2:9][C:4]=2[C:3]=1[C:11](=[O:19])[C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 113464461-(2-Iodoethyl)-4-nitrobenzeneHCID 154344552-Amino-3-(4-chlorobenzoyl)-4,5,6,7-tetrahydrothieno(2,3-c)pyridine

Product 1

HCID 154344522-Amino-3-(4-chloro-benzoyl)-6-[4-nitro-(2-phenyleth-1-yl)]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Procedure

The same procedure as in Example 17 was used except an equivalent amount of 2-amino-3-(4-chloro-benzoyl) 4,5,6,7-tetrahydrothieno[2,3-c]pyridine is used in place of 2-Amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (2 mmol), and an equivalent amount of p-nitrophenylethyl iodide was used in place of methyl iodide (3 mmol).

Sources & evidence

ORD record
ord-d7550a91c1f7461a8c9e581bc458cf91
Source dataset
uspto-grants-2001_02
Patent number
US06194449B1

Reaction notes

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