反应详情

A mixture of 3-isopropyl-4-methoxyphenol (200 mg), 4-chloro-3-cyano-5-methylnitrobenzene (200 mg) and potassium carbonate (211 mg) in methylethylketone (8 mL) was refluxed for 18 h. The dark mixture was concentrated in vacuo, partitioned between ethyl acetate/water, the organic layer washed with about 2N sodium hydroxide, brine, dried over sodium sulfate and concentrated to a dark oil. Flash chromatography (10% ethyl acetate/hexanes) afforded 2-(3-isopropyl-4-methoxy-phenoxy)-3-methyl-5-nitrobenzonitrile as a yellow oil (300 mg).

1. temperaturewas refluxed for 18 h
2. concentrationThe dark mixture was concentrated in vacuo
3. custompartitioned between ethyl acetate/water
4. washthe organic layer washed with about 2N sodium hydroxide, brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated to a dark oil