反应详情

温度

5 °C

To a suspension of 2-methoxybenzaldehyde (622.4 mg, 4.57 mmol), 1,1-dimethylnitroethane (942.7 mg, 9.14 mmol) and zinc (896.3 mg, 13.7 mmol) in ethanol (15 ml) was added acetic acid (944.8 mg, 15.7 mmol) dropwise at 5° C. while stirring. The mixture was stirred at room temperature for one day. After the mixture was cooled to 5° C., zinc acetate was filtered off and the filtrate was concentrated and purified by silica gel chromatography (hexane/ethyl acetate=2/1).

1. stirringThe mixture was stirred at room temperature for one day
2. filtrationzinc acetate was filtered off
3. concentrationthe filtrate was concentrated
4. custompurified by silica gel chromatography (hexane/ethyl acetate=2/1)