1,3-Thiazole-2-carboximidamide hydrochloride → 4-Cyclopropyl-thiazole-2-carboxamidine

HRID 63677Notes

Reaction equation

HRID 63677 reaction equation
Cl.[S:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([NH2:9])=[NH:8].[CH:10]1(C2N=C(C#N)SC=2)[CH2:12][CH2:11]1>>[CH:10]1([C:5]2[N:4]=[C:3]([C:7]([NH2:9])=[NH:8])[S:2][CH:6]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 186795841,3-Thiazole-2-carboximidamide hydrochloride2×HCID 717485734-Cyclopropylthiazole-2-carbonitrile

Product 1

HCID 900009164-Cyclopropyl-thiazole-2-carboxamidine

Procedure

Compound M was prepared in analogy to thiazole-2-carboxamidine (Compound A1) with the procedure shown in Scheme 5 by using 4-cyclopropyl-thiazole-2-carbonitrile instead of thiazole-2-carbonitrile. 1H NMR (CDCl3-d, 400 MHz): δ 9.68 (br, 1H), 9.56 (br, 1H), 2.23-2.19 (m, 1H), 1.01-0.92 (m, 4H).

Sources & evidence

ORD record
ord-667638fcd2214222959aa2d16d018834
Source dataset
uspto-grants-2016_09
Patent number
US09447086B2

Reaction notes

Loading…