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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 63677Generated: October 27, 2026

1,3-Thiazole-2-carboximidamide hydrochloride → 4-Cyclopropyl-thiazole-2-carboxamidine

https://huagongshe.com/reaction/63677

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Thiazole-2-carboximidamide hydrochlorideHCID 18679584—
Reactant4-Cyclopropylthiazole-2-carbonitrileHCID 71748573—
Product4-Cyclopropyl-thiazole-2-carboxamidineHCID 90000916—

Reaction Steps

Compound M was prepared in analogy to thiazole-2-carboxamidine (Compound A1) with the procedure shown in Scheme 5 by using 4-cyclopropyl-thiazole-2-carbonitrile instead of thiazole-2-carbonitrile. 1H NMR (CDCl3-d, 400 MHz): δ 9.68 (br, 1H), 9.56 (br, 1H), 2.23-2.19 (m, 1H), 1.01-0.92 (m, 4H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447086B2
Source datasetuspto-grants-2016_09
ORD IDord-667638fcd2214222959aa2d16d018834
Source noteuspto-grants-2016_09