4-Methylpiperidine-1-sulfonyl chloride → HCID 70225375, compound

HRID 636799Notes

Reaction equation

HRID 636799 reaction equation
[CH:1]12[CH:6]([N:7]3[C:11](=[O:12])[C:10]([CH2:20][C:21]4[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=4)([CH2:13][C:14]4[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=4)[NH:9][C:8]3=[CH:27][C:28]([C:30]3[CH:37]=[CH:36][C:33]([C:34]#[N:35])=[CH:32][CH:31]=3)=[O:29])[CH:5]1[CH2:4][NH:3][CH2:2]2.[CH3:38][CH:39]1[CH2:44][CH2:43][N:42]([S:45](Cl)(=[O:47])=[O:46])[CH2:41][CH2:40]1>>[CH3:38][CH:39]1[CH2:44][CH2:43][N:42]([S:45]([N:3]2[CH2:4][CH:5]3[CH:1]([CH:6]3[N:7]3[C:11](=[O:12])[C:10]([CH2:20][C:21]4[CH:22]=[CH:23][N:24]=[CH:25][CH:26]=4)([CH2:13][C:14]4[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=4)[NH:9][C:8]3=[CH:27][C:28]([C:30]3[CH:31]=[CH:32][C:33]([C:34]#[N:35])=[CH:36][CH:37]=3)=[O:29])[CH2:2]2)(=[O:47])=[O:46])[CH2:41][CH2:40]1

Participants

3

Reactant 2

HCID 162284464-Methylpiperidine-1-sulfonyl chlorideHCID 70224708HCID 70224708, compound

Product 1

HCID 70225375HCID 70225375, compoundYield 93.1%

Procedure

According to the procedure of Example 13, 4-{[1-(3-aza-bicyclo[3.1.0]hex-6-yl)-5-oxo-4,4-bis-pyridin-4-ylmethyl-imidazolidin-2-ylidene]-acetyl}-benzonitrile (50 mg, 0.102 mmol) and 4-methyl-piperidine-1-sulfonyl chloride (60.2 mg, 0.306 mmol) were reacted to generate the title compound as an off-white solid (62 mg, 0.095 mmol, 93% yield).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-a445547961fa438789ca688dd94df9be
Source dataset
uspto-grants-2001_02
Patent number
US06194438B1

Reaction notes

Loading…