1-Bromo-3-methylbutan-2-one → 4-Isopropyl-thiazole-2-carboxamidine

HRID 63680Notes

Reaction equation

HRID 63680 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]([C:9]([NH2:11])=[NH:10])[S:7][CH:8]=2)[CH2:3][CH2:2]1.BrCC(=O)C(C)C>>[CH:1]([C:4]1[N:5]=[C:6]([C:9]([NH2:11])=[NH:10])[S:7][CH:8]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 108990371-Bromo-3-methylbutan-2-oneHCID 900009164-Cyclopropyl-thiazole-2-carboxamidine

Product 1

HCID 899961514-Isopropyl-thiazole-2-carboxamidine

Procedure

4-Isopropyl-thiazole-2-carboxamidine (Compound V) was prepared in analogy to Compound M with procedure shown in Example 10 by using 1-bromo-3-methyl-butan-2-one instead of 2-bromo-1-cyclopropyl-ethanone. MS: calc'd (MH+) 170, measured (MH+) 170.

Sources & evidence

ORD record
ord-425468a008e94181855ed6b1cddfc0ba
Source dataset
uspto-grants-2016_09
Patent number
US09447086B2

Reaction notes

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