HCID 21255336, compound → HCID 88219294, compound

HRID 636800Notes

Reaction equation

HRID 636800 reaction equation
[O:1]([C:6]([N:8]1[CH2:13][CH:12]2[CH:10]([CH:11]2[N:14]=[C:15]=[S:16])[CH2:9]1)=[O:7])[C:2]([CH3:5])([CH3:4])[CH3:3].C[O:18][C:19](=O)[C:20]([NH2:31])([CH2:28][CH:29]=[CH2:30])[CH2:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1>>[C:2]([O:1][C:6]([N:8]1[CH2:13][CH:12]2[CH:10]([CH:11]2[N:14]2[C:19](=[O:18])[C:20]([CH2:28][CH:29]=[CH2:30])([CH2:21][C:22]3[CH:23]=[CH:24][N:25]=[CH:26][CH:27]=3)[NH:31][C:15]2=[S:16])[CH2:9]1)=[O:7])([CH3:3])([CH3:4])[CH3:5]

Participants

3

Reactant 2

HCID 21255336HCID 21255336, compoundHCID 54085815HCID 54085815, compound

Product 1

HCID 88219294HCID 88219294, compoundYield 88%

Procedure

Using the same procedure as described in Example 2B, 3-(tert-butoxylcarbonyl)-6-isothiocyanato-3-aza-bicyclo[3.1.0]hexane (23.4 mmol, prepared in 1A) and 2-amino-2-allyl-3-pyridin-4-yl-propionic acid methyl ester (11.6 mmol) were reacted to afford the title compound of 30A (4.37 g, 10.2 mmol, 88% yield).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-92b309335d5642bc9c263be58f44178c
Source dataset
uspto-grants-2001_02
Patent number
US06194438B1

Reaction notes

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