2-Thiophenesulfonyl chloride → HCID 70222801, compound

HRID 636808Notes

Reaction equation

HRID 636808 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:5](=[CH:14][C:15]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=2)=[O:16])[NH:4][C:3]1([CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1)[CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1.[S:39]1[CH:43]=[CH:42][CH:41]=[C:40]1[S:44](Cl)(=[O:46])=[O:45]>>[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:13][CH2:12][N:11]([S:44]([C:40]3[S:39][CH:43]=[CH:42][CH:41]=3)(=[O:46])=[O:45])[CH2:10][CH2:9]2)[C:5](=[CH:14][C:15]([C:17]2[CH:18]=[CH:19][C:20]([C:21]#[N:22])=[CH:23][CH:24]=2)=[O:16])[NH:4][C:3]1([CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1)[CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 855182-Thiophenesulfonyl chlorideHCID 70225437HCID 70225437, compound

Product 1

HCID 70222801HCID 70222801, compound

Procedure

According to the procedure of Example 13, the title compound of 40B (36 mg, 0.071 mmol) and thiophene-2-sulfonyl chloride (16 mg, 0.085 mmol) were reacted to generate the title compound (9 mg, 0.014 mmol,19% yield).

Sources & evidence

ORD record
ord-7b49437854fe4ff48dad17ae07069953
Source dataset
uspto-grants-2001_02
Patent number
US06194438B1

Reaction notes

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