Trifluoroacetic acid → HCID 70225090, compound

HRID 636810Notes

Reaction equation

HRID 636810 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:12][CH2:11][N:10](C(OCCCC)=O)[CH2:9]2)[C:5](=[CH:20][C:21]([C:23]2[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=2)=[O:22])[NH:4][C:3]1([CH2:38][C:39]1[CH:44]=[CH:43][N:42]=[CH:41][CH:40]=1)[CH2:31][C:32]1[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:12][CH2:11][NH:10][CH2:9]2)[C:5](=[CH:20][C:21]([C:23]2[CH:24]=[CH:25][C:26]([C:27]#[N:28])=[CH:29][CH:30]=2)=[O:22])[NH:4][C:3]1([CH2:31][C:32]1[CH:33]=[CH:34][N:35]=[CH:36][CH:37]=1)[CH2:38][C:39]1[CH:44]=[CH:43][N:42]=[CH:41][CH:40]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70225096HCID 70225096, compound

Product 1

HCID 70225090HCID 70225090, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using the same procedure as described in Example 3, the title compound of 46A (6.73 mmol) was treated with TFA (10 ml) in CH2Cl2 to give the title compound of 46B (2.232 g, 4.53 mmol, 78% yield).

Sources & evidence

ORD record
ord-f3d5b381a1b2424da6ca47d56df872ba
Source dataset
uspto-grants-2001_02
Patent number
US06194438B1

Reaction notes

Loading…