Trifluoroacetic acid → 3-Methylmorpholine-3-carboxylic acid

HRID 63685Notes

Reaction equation

HRID 63685 reaction equation
[CH3:1][C:2]1([C:15]([OH:17])=[O:16])[CH2:7][O:6][CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1([C:15]([OH:17])=[O:16])[CH2:7][O:6][CH2:5][CH2:4][NH:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 223091424-((Tert-butoxy)carbonyl)-3-methylmorpholine-3-carboxylic acid

Product 1

HCID 836796483-Methylmorpholine-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-methyl-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-3-carboxylic acid (Accela ChemBio Co., Ltd., CAS: 1052680-53-1, 50 mg, 0.2.0 mmol) in DCM (1 ml) was added trifluoroacetic acid (1 mL) dropwise at room temperature. The resulting mixture was stirred at room temperature for one hour and then concentrated under the vacuum. The residue was used directly in next step without further purification,

Workup

  1. concentrationconcentrated under the vacuum
  2. customThe residue was used directly in next step without further purification

Sources & evidence

ORD record
ord-908386cd59a441989ed9d68678a1eedf
Source dataset
uspto-grants-2016_09
Patent number
US09447086B2

Reaction notes

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