7-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride → 7-Methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	7-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride	HCID 22665676	—
Reactant	N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxy)-benzenesulfonamide	HCID 22665795	—
Product	7-Methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide	HCID 86756458	—

Reaction Steps

This compound was prepared from 200 mg of 7-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride and 210 mg of 30a using the procedure described for 58c. Yield: 110 mg; m.p. 175-1 76° C., (+)-FAB-MS: 544 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06194409B1
Source dataset	uspto-grants-2001_02
ORD ID	ord-4ec2ebdd60824364adfd96dcd8e0a064
Source note	uspto-grants-2001_02