Sulfuryl chloride → 7-Methoxy-2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride

HRID 636959Notes

Reaction equation

HRID 636959 reaction equation
S(Cl)(Cl)(=O)=[O:2].[CH3:6][O:7][C:8]1[CH:17]=[C:16]2[C:11]([CH2:12][CH2:13][N:14]([S:18]([Cl:21])(=[O:20])=[O:19])[CH2:15]2)=[CH:10][CH:9]=1>C(N(CC)CC)C>[CH3:6][O:7][C:8]1[CH:9]=[CH:10][C:11]2[O:2][CH2:12][CH2:13][N:14]([S:18]([Cl:21])(=[O:20])=[O:19])[CH2:15][C:16]=2[CH:17]=1

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 226656767-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride

Product 1

HCID 226656217-Methoxy-2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

This compound was prepared from 1.4 g of 7-methoxy-2,3,4,5-tetrahydro-benzo[f[1,4]-oxazepine, 0.91 mL of sulfuryl chloride and 4.7 mL of triethylamine using the procedure described for 63f. Yield: 0.23 g (oil), EI-MS: 277 (M+).

Sources & evidence

ORD record
ord-c893c39c21d840d1b958f53a313e1c15
Source dataset
uspto-grants-2001_02
Patent number
US06194409B1

Reaction notes

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