huagongshe.com
HRID637004

反应详情

EQUATION

反应方程式

HRID 637004 的结构方程式

REACTANTS

反应物

4
结构：CN1CCOCC1
HCID7972

4-Methylmorpholine

C5H11NO

结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O
HCID85083

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

C10H17NO4

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：NCc1ccc2c(N)nccc2c1
HCID22169775

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NCc1ccc2c(N)nccc2c1
HCID22958562

未命名化合物

收率 100.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

5.00 g of 1-Amino-6-aminomethyl-isoquinoline and 6.20 g Boc-L-proline were dissolved in 88 mL DMF. 10.6 g of TBTU was added followed by a dropwise addition of N-methylmorpholine. Stirring was continued for 1 h at ambient temperature and the solvent was removed i.vac. The residue was extracted with 5% aqueous NaHCO3 solution and with ethyl acetate. The organic layer was separated and dried (NaSO4). The solvent was removed to give 10.7 g (quant.) of N-(1-Amino-isoquinolin-6-ylmethyl)-1-tert.butoxycarbonyl-prolinamide as an oil.

WORKUP

后处理

  1. customthe solvent was removed i.vac
  2. extractionThe residue was extracted with 5% aqueous NaHCO3 solution and with ethyl acetate
  3. customThe organic layer was separated
  4. dry with materialdried (NaSO4)
  5. customThe solvent was removed