反应详情

Combine N-(2-ethoxyethyl)-2-nitroaniline (85.4 g, 406 mmol) and ethanol (300 mL). Add a solution of sodium hydroxide (6 g) in water (60 mL). Heat to reflux. Remove the heating and add portionwise zinc metal (106 g, 1.62 mol) at a rate such that the reaction is maintained at reflux. After the addition of zinc metal is complete stir for 30 minutes. Filter the reaction mixture and rinse with water. Extract the filtrate three times with ethyl acetate. Dry the combined organic layers over Na2SO4, filter, and evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting with ethyl acetate to give 1-(2-ethoxyethyl)-1,2-phenylenediamine.

1. temperatureHeat to reflux
2. customRemove the heating and
3. temperatureis maintained
4. temperatureat reflux
5. filtrationFilter the reaction mixture
6. washrinse with water
7. extractionExtract the filtrate three times with ethyl acetate
8. dry with materialDry the combined organic layers over Na2SO4
9. filtrationfilter
10. customevaporate in vacuo
11. customto give a residue