反应详情

Combine 1-(t-butoxycarbonyl)-4-(1-(2-(1H-imidazol-1-yl)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (0.22 g, 0.54 mmol), 57% hydriodic acid (0.25 mL, 1.13 mmol), methanol (10 mL) and heat to reflux. After 20 hours, cool the reaction mixture and evaporate in vacuo to give a residue. Triturate the residue with diethyl ether to give a solid. Repeatedly, decant and add diethyl ether before collecting the solid by filtration, rinse with diethyl ether, and dry in vacuo to give the title compound.

1. temperaturecool the reaction mixture
2. customevaporate in vacuo
3. customto give a residue
4. customTriturate the residue with diethyl ether
5. customto give a solid
6. customRepeatedly, decant
7. additionadd diethyl ether
8. custombefore collecting the solid
9. filtrationby filtration
10. washrinse with diethyl ether
11. customdry in vacuo