Hydrogen iodide → 4-(1-(2-(1H-tetrazol-1-yl)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane hydriodic Acid Salt

HRID 637156Notes

Reaction equation

HRID 637156 reaction equation
[N:1]1([CH2:6][CH2:7][N:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[N:17]2[CH2:23][CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[CH:5]=[N:4][N:3]=[N:2]1.[IH:24]>CO>[IH:24].[N:1]1([CH2:6][CH2:7][N:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[N:17]2[CH2:23][CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[CH:5]=[N:4][N:3]=[N:2]1

Participants

4

Reactant 2

HCID 24841Hydrogen iodideHCID 184644964-(1-(2-(1H-tetrazol-1-yl)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane

Product 1

HCID 865838964-(1-(2-(1H-tetrazol-1-yl)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane hydriodic Acid Salt

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Combine 4-(1-(2-(1H-tetrazol-1-yl)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (0.30 g, 0.96 mmol) and methanol (10 mL). Add hydriodic acid (0.27 mL, 57%, 2.02 mmol). After 2 hour, evaporate in vacuo to give a residue. Triturate the residue with diethyl ether (about 20 mL) to give a solid. Collect the solid and dry to give the title compound.

Workup

  1. customevaporate in vacuo
  2. customto give a residue
  3. customTriturate the residue with diethyl ether (about 20 mL)
  4. customto give a solid
  5. customCollect the solid
  6. customdry

Sources & evidence

ORD record
ord-627b537b292a4f4b98871e61d7b72b7c
Source dataset
uspto-grants-2001_02
Patent number
US06194406B1

Reaction notes

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