反应详情

Combine methyl 2-methyl-5-(1H-tetrazol-1-yl)benzoate (5.2 g, 23.9 mmol) and lithium hydroxide hydrate (2.0 g, 47.7 mmol) in tetrahydrofuran/water (50 mL/50 mL). Heat to reflux. After 2 hours, dilute with diethyl ether and separate the layers. Extract the aqueous layer three times with diethyl ether. Extract the combined diethyl ether layers three times with a 1 M sodium hydroxide solution (20 mL). Combine the aqueous layers, acidify with a 1 M aqueous hydrochloric acid solution (pH about 1) to give a solid. Collect the solid by filtration and recrystallize form water to give the title compound.

1. temperatureHeat to reflux
2. customseparate the layers
3. extractionExtract the aqueous layer three times with diethyl ether
4. extractionExtract the combined diethyl ether layers three times with a 1 M sodium hydroxide solution (20 mL)
5. customto give a solid
6. customCollect the solid
7. filtrationby filtration
8. customrecrystallize
9. customform water