Lithium Hydroxide → 5-Cyano-2-methoxybenzoic acid

HRID 637205Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Li+]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 18464789Methyl 5-cyano-2-methoxybenzoate

Product 1

HCID 219425685-Cyano-2-methoxybenzoic acid

Procedure

Hydrolyze methyl 2-methoxy-5-cyanobenzoate by the method of Preparation 24 using 1.1 equivalents of lithium hydroxide to give the title compound.

Sources & evidence

ORD record: ord-a6e72462cc7246aaade5fda40863ad66
Source dataset: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06194406B1

Reaction notes

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