HCID 18465020, compound → HCID 18464884, compound

HRID 637209Notes

Reaction equation

HRID 637209 reaction equation
[CH3:1][O:2][C:3]1[CH:37]=[CH:36][CH:35]=[CH:34][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][C:8]([CH2:18][C:19]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=2)([CH2:11][CH2:12]OS(C)(=O)=O)[C:7]1=[O:33].I.[CH2:39]([O:41][CH2:42][CH2:43][N:44]1[C:48]2[CH:49]=[CH:50][CH:51]=[CH:52][C:47]=2[N:46]=[C:45]1[N:53]1[CH2:59][CH2:58][CH2:57][NH:56][CH2:55][CH2:54]1)[CH3:40]>>[CH3:1][O:2][C:3]1[CH:37]=[CH:36][CH:35]=[CH:34][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][C:8]([CH2:11][CH2:12][N:56]2[CH2:57][CH2:58][CH2:59][N:53]([C:45]3[N:44]([CH2:43][CH2:42][O:41][CH2:39][CH3:40])[C:48]4[CH:49]=[CH:50][CH:51]=[CH:52][C:47]=4[N:46]=3)[CH2:54][CH2:55]2)([CH2:18][C:19]2[CH:20]=[C:21]([C:29]([F:31])([F:30])[F:32])[CH:22]=[C:23]([C:25]([F:27])([F:26])[F:28])[CH:24]=2)[C:7]1=[O:33]

Participants

3

Reactant 2

HCID 18465020HCID 18465020, compoundHCID 865838874-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl) [1,4]diazepane hydriodic acid salt

Product 1

HCID 18464884HCID 18464884, compound

Procedure

Prepare by the method of Example 7.6 using 1-(2-methoxybenzyl)-3-(3 5-di(trifluoromethyl)phenylmethyl)-3-(2-methanesulfonyloxyethyl)-2-oxopyrrolidine and 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane hydriodic acid salt to give the title compound: Rf=0.54 (silica gel, 5% methanol/dichloromethane/0.5% concentrated aqueous ammonia).

Sources & evidence

ORD record
ord-f7a3ad18eacc464aace07c87a9251cc8
Source dataset
uspto-grants-2001_02
Patent number
US06194406B1

Reaction notes

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