Hydrochloric Acid → 4-(fur-2-ylmethyl-1H-benzimidazol-2-yl)[1,4]diazepane hydrochloric acid salt

HRID 637216Notes

Reaction equation

HRID 637216 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:19]([CH2:20][C:21]3[O:22][CH:23]=[CH:24][CH:25]=3)[C:18]3[CH:26]=[CH:27][CH:28]=[CH:29][C:17]=3[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:30].C(OCC)C>O1CCOCC1>[ClH:30].[O:22]1[CH:23]=[CH:24][CH:25]=[C:21]1[CH2:20][N:19]1[C:18]2[CH:26]=[CH:27][CH:28]=[CH:29][C:17]=2[N:16]=[C:15]1[N:11]1[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 184648751-(t-butoxycarbonyl)-4-(fur-2-ylmethyl-1H-benzimidazol-2-yl)[1,4]diazepane

Product 1

HCID 698341014-(fur-2-ylmethyl-1H-benzimidazol-2-yl)[1,4]diazepane hydrochloric acid salt

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Combine 1-(t-butoxycarbonyl)-4-(fur-2-ylmethyl-1H-benzimidazol-2-yl)[1,4]diazepane (0.6 g, 1.5 mmol) and dioxane (10 mL). Add a solution of hydrochloric acid in dioxane (6 mL, 4 M). After 1 hour, add diethyl ether (50 mL) to give a solid. Collect the solid by filtration and dry to give 4-(fur-2-ylmethyl-1H-benzimidazol-2-yl)[1,4]diazepane hydrochloric acid salt: 219-221° C.

Workup

  1. customto give a solid
  2. customCollect the solid
  3. filtrationby filtration
  4. customdry

Sources & evidence

ORD record
ord-a571c5393d6847ce8b171b43316959a8
Source dataset
uspto-grants-2001_02
Patent number
US06194406B1

Reaction notes

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