反应详情

Combine 1-(t-butoxycarbonyl)-4-(1-(4-fluorobenzyl-1H-benzimidazol-2-yl)[1,4]diazepane (2.50 g, 5.89 mmol), aqueous hydriodic acid (5 mL, 57%), and ethanol (10 mL). Heat to reflux. After 1 hour, cool to ambient temperature and pour the reaction mixture into diethyl ether (450 mL) and stir to give a solid. After 1 hour, collect the solid by filtration, rinse with diethyl ether, and dry in vacuo to give the title compound: Rf=0.16 (silica gel, dichloromethane/methanol/concentrated aqueous ammonia 90/10/0.1).

1. temperatureHeat to reflux
2. customto give a solid
3. waitAfter 1 hour
4. customcollect the solid
5. filtrationby filtration
6. washrinse with diethyl ether
7. customdry in vacuo