Sodium Carbonate → 11-[2-[4-(3-Hydroxypropyl)piperazin-1-yl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

HRID 637285Notes

Reaction equation

HRID 637285 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][OH:10])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[CH2:12][C:13]([N:15]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[C:19](=[O:26])[NH:18][C:17]2[CH:27]=[CH:28][CH:29]=[N:30][C:16]1=2)=[O:14].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[OH:10][CH2:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][N:4]([CH2:12][C:13]([N:15]2[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[C:19](=[O:26])[NH:18][C:17]3[CH:27]=[CH:28][CH:29]=[N:30][C:16]2=3)=[O:14])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 79207Piperazin-1-ylpropanolHCID 12005311-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one

Product 1

HCID 2025676011-[2-[4-(3-Hydroxypropyl)piperazin-1-yl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Piperazinepropanol (8 g) was added to a suspension of 11-(2-chloroacetyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one (15 g) and anhydrous sodium carbonate (15 g) in absolute ethanol (250 ml).

Sources & evidence

ORD record
ord-36df0d5ded8f420ab2cab018c43b07e8
Source dataset
uspto-grants-1985_12
Patent number
US04556653

Reaction notes

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