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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 637285Generated: October 30, 2026

Sodium Carbonate → 11-[2-[4-(3-Hydroxypropyl)piperazin-1-yl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

https://huagongshe.com/reaction/637285

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium CarbonateHCID 10340—
ReactantPiperazin-1-ylpropanolHCID 79207—
Reactant11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 120053—
SolventEthanolHCID 702—
Product11-[2-[4-(3-Hydroxypropyl)piperazin-1-yl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 20256760—

Reaction Steps

1-Piperazinepropanol (8 g) was added to a suspension of 11-(2-chloroacetyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one (15 g) and anhydrous sodium carbonate (15 g) in absolute ethanol (250 ml).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04556653
Source datasetuspto-grants-1985_12
ORD IDord-36df0d5ded8f420ab2cab018c43b07e8
Source noteuspto-grants-1985_12