Hydrochloric Acid → HCID 13500726, compound

HRID 637286Notes

Reaction equation

HRID 637286 reaction equation
[C:1]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C@@H:16]([C:18]([OH:20])=[O:19])[NH2:17])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].Cl.[CH2:22](O)[CH3:23]>>[CH2:22]([O:19][C:18](=[O:20])[C@H:16]([CH2:15][CH2:14][CH2:13][CH2:12][NH:11][C:1]([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2])[NH2:17])[CH3:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 1715626epsilon-(Benzyloxycarbonyl)-L-lysine

Product 1

HCID 13500726HCID 13500726, compound

Procedure

To Nε-carbobenzoxy-L-lysine (69.7 g) was added ethanol (1000 ml) which had been saturated with anhydrous hydrogen chloride. The resulting solution was stirred at room temperature for three days. Ethanol was evaporated in vacuo and the residue was taken up in chloroform (500-600 ml). The chloroform was washed twice with saturated aqueous sodium bicarbonate, filtered and evaporated to afford the desired product as a colorless oil (69.9 g).

Workup

  1. customEthanol was evaporated in vacuo
  2. washThe chloroform was washed twice with saturated aqueous sodium bicarbonate
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-51495cf677c34bca8f9ea43eef115c87
Source dataset
uspto-grants-1985_12
Patent number
US04556652

Reaction notes

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