Methane → HCID 13192325, compound

HRID 637313Notes

Reaction equation

HRID 637313 reaction equation
C.Cl.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[NH:11][C:12]([C:14]1[S:18][C:17]2=[N:19][CH2:20][CH2:21][N:16]2[C:15]=1[CH3:22])=[O:13]>O>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[NH:11][C:12]([C:14]1[S:18][C:17]2=[N:19][CH2:20][CH2:21][N:16]2[C:15]=1[CH3:22])=[O:13]

Participants

4

Reactant 2

HCID 297MethaneHCID 13192326HCID 13192326, compound2×

Product 1

HCID 13192325HCID 13192325, compoundYield 95.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A small amount of active charcoal was added to 2-(2,5-dichlorophenyl-carbamoyl)-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride (compound 8) (9.1 g, 0.025M) dissolved in water (300 ml), and the mixture was stirred for 10 minutes and filtered. Pyridine was added to the filtrate with stirring to adjust the pH to alkaline. The precipitated crystals were collected by filtration, completely washed with water and dried to obtain compound 7 as white powdery crystals. (8.7 g, yield: 95.6%)

Workup

  1. filtrationfiltered
  2. additionPyridine was added to the filtrate
  3. stirringwith stirring
  4. filtrationThe precipitated crystals were collected by filtration
  5. washcompletely washed with water
  6. customdried

Sources & evidence

ORD record
ord-f1753aa18318481db56998cf77e5ec68
Source dataset
uspto-grants-1985_12
Patent number
US04556669

Reaction notes

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