HCID 13175275, compound → HCID 53921704, compound

HRID 637380Notes

Reaction equation

HRID 637380 reaction equation
[CH2:1]([CH:3]([C:9](O)([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]>C(Cl)(Cl)Cl.FC(F)(F)C(O)=O>[CH2:1]([C:3](=[C:9]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 13175275HCID 13175275, compound

Product 1

HCID 53921704HCID 53921704, compoundYield 107.9%

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidCatalystHCID 6212ChloroformSolvent

Procedure

7.3 g (0.02 mol) of ethyl 2-ethyl-3-hydroxy-3-(p-methoxyphenyl)-3-phenylpropionate were dehydrated in 150 ml of chloroform by using trifluoroacetic acid as catalyst (see example 10) to give 6.7 g (93%) of product, which was a mixture of E- and Z-isomers.

Sources & evidence

ORD record
ord-4e0a030a0d4a4ecc8ce1cd515e4125d7
Source dataset
uspto-grants-1985_12
Patent number
US04556677

Reaction notes

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