1-Methylpiperazine → HCID 20256972, compound

HRID 637432Notes

Reaction equation

HRID 637432 reaction equation
C(S[C:4]1[N:5]=[CH:6][C:7]2[C:13](=[O:14])[C:12]([C:15]([OH:17])=[O:16])=[CH:11][N:10]([CH:18]3[CH2:20][CH2:19]3)[C:8]=2[N:9]=1)C.[CH3:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[CH3:21][N:22]1[CH2:27][CH2:26][N:25]([C:4]2[N:5]=[CH:6][C:7]3[C:13](=[O:14])[C:12]([C:15]([OH:17])=[O:16])=[CH:11][N:10]([CH:18]4[CH2:19][CH2:20]4)[C:8]=3[N:9]=2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 20256976HCID 20256976, compound

Product 1

HCID 20256972HCID 20256972, compound

Procedure

A solution of 2.91 g of 2-ethylmercapto-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid and 2.2 l g of N-methylpiperazine in 30 ml of N-dimethylformamide is heated at 110° for 2.5 hours. The solvent is distilled off in vacuo and the residue is recrystallised from ethanol. 2.4 g (73% of the theoretical yield) of 2-(4-methyl-piperazino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid with a melting point of 209°-210° C. are obtained.

Workup

  1. distillationThe solvent is distilled off in vacuo
  2. customthe residue is recrystallised from ethanol

Sources & evidence

ORD record
ord-cfa42c0398c54fe59f7c2017d34f840d
Source dataset
uspto-grants-1985_12
Patent number
US04556709

Reaction notes

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