Sodium hydride → HCID 20184113, compound

HRID 637472Notes

Reaction equation

HRID 637472 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[NH:11][C:10]3[N:18]=[CH:19][CH:20]=[CH:21][C:9]=3[N:8]=2)=[CH:3][CH:2]=1.[H-].[Na+].[CH3:24][N:25]([CH3:30])[CH2:26][CH2:27][CH2:28]Cl>>[CH3:24][N:25]([CH3:30])[CH2:26][CH2:27][CH2:28][N:11]1[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:7]([C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)=[N:8][C:9]2[CH:21]=[CH:20][CH:19]=[N:18][C:10]1=2

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 135626379HCID 135626379, compound

Product 1

HCID 20184113HCID 20184113, compound

Procedure

Following the procedure of Example 23, 6-(4-pyridinyl)-11H-pyrido[2,3-b][1,4]-benzodiazepine is reacted with sodium hydride followed by reaction with 3-dimethylaminopropyl chloride.

Sources & evidence

ORD record
ord-cf51d6f8e8b54163b82abbf16be21e8f
Source dataset
uspto-grants-1985_12
Patent number
US04556667

Reaction notes

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