反应详情

To a stirred solution of 5-(4-aminophenyl)-2-(1H)-pyrazinone hydrobromide (1.3 g) in dimethylformamide (20 ml) containing pyridine (1 ml) was added a solution of isonicotinyl chloride hydrochloride (1.3 g) in dimethylformamide (10 ml). The mixture was heated under reflux for 4 hours and evaporated to small volume. Water was added to the residue and the solid (1.0 g) was collected, washed with water, dilute sodium hydroxide solution (pH8), water and then dried to give the title compound m.p. 303°-308° C.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 4 hours
3. customevaporated to small volume
4. additionWater was added to the residue
5. customthe solid (1.0 g) was collected
6. washwashed with water, dilute sodium hydroxide solution (pH8), water
7. customdried