HRID63751

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCOC(=O)[C@H](Cc1ccc(-c2c(C)n(C)c(=O)n(C)c2=O)cc1)NC(=O)c1c(F)cc(C#N)cc1F

HCID86691353

未命名化合物

PRODUCTS

生成物

结构：CCCOC(=O)[C@H](Cc1ccc(-c2c(C)n(C)c(=O)n(C)c2=O)cc1)NC(=O)c1c(F)cc(CNCc2cc(F)c(C(=O)N[C@@H](Cc3ccc(-c4c(C)n(C)c(=O)n(C)c4=O)cc3)C(=O)OCCC)c(F)c2)cc1F

HCID89720749

未命名化合物

收率 39.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1031

1-Propanol

C3H8O

PROCEDURE

实验过程

To a 100 mL flask containing (S)-2-(4-cyano-2,6-difluorobenzoylamino)-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)phenyl]propionic acid propyl ester (524 mg, 1.0 mmol) dissolved in n-propanol (20 mL) purged with nitrogen was added palladium on carbon (10%, 106 mg). The reaction was sealed, degassed with three exposures to nitrogen and house vacuum, and then exposed to a balloon of hydrogen overnight. The reaction was diluted with EA, degassed again, and exposed to hydrogen overnight. The reaction was filtered through celite, concentrated and purified by HPLC yielding the title compound (204 mg, 19%). ES(+)-LRMS m/e calcd. for C54H57F4N7O10 (M+H)+ 1041, obsd 1041.

WORKUP

后处理

custompurged with nitrogen
additionwas added palladium on carbon (10%, 106 mg)
customThe reaction was sealed
customdegassed with three exposures to nitrogen and house vacuum
customexposed to a balloon of hydrogen overnight
additionThe reaction was diluted with EA
customdegassed again
customexposed to hydrogen overnight
filtrationThe reaction was filtered through celite,
concentrationconcentrated
custompurified by HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d101ae79daf44e73a29fe5c00293093e
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09447035B2
来源说明: uspto-grants-2016_09

反应 SMILES

[CH2:1]([O:4][C:5](=[O:38])[C@@H:6]([NH:25][C:26](=[O:37])[C:27]1[C:32]([F:33])=[CH:31][C:30]([C:34]#[N:35])=[CH:29][C:28]=1[F:36])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:15](=[O:24])[N:16]([CH3:23])[C:17](=[O:22])[N:18]([CH3:21])[C:19]=2[CH3:20])=[CH:10][CH:9]=1)[CH2:2][CH3:3]>C(O)CC>[CH2:1]([O:4][C:5](=[O:38])[C@@H:6]([NH:25][C:26](=[O:37])[C:27]1[C:28]([F:36])=[CH:29][C:30]([CH2:34][NH:35][CH2:34][C:30]2[CH:29]=[C:28]([F:36])[C:27]([C:26](=[O:37])[NH:25][C@H:6]([C:5]([O:4][CH2:1][CH2:2][CH3:3])=[O:38])[CH2:7][C:8]3[CH:9]=[CH:10][C:11]([C:14]4[C:15](=[O:24])[N:16]([CH3:23])[C:17](=[O:22])[N:18]([CH3:21])[C:19]=4[CH3:20])=[CH:12][CH:13]=3)=[C:32]([F:33])[CH:31]=2)=[CH:31][C:32]=1[F:33])[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[C:15](=[O:24])[N:16]([CH3:23])[C:17](=[O:22])[N:18]([CH3:21])[C:19]=2[CH3:20])=[CH:12][CH:13]=1)[CH2:2][CH3:3]