Dichloromethane → HCID 20257053, compound

HRID 637540Notes

Reaction equation

HRID 637540 reaction equation
[C:1]1([CH3:12])[CH:6]=[CH:5][C:4]([S:7]([O:10]C)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:13][S:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[O:24][CH2:25][CH:26]([OH:29])[CH2:27][OH:28].[CH2:30](Cl)Cl>CCOCC>[C:1]1([CH3:12])[CH:2]=[CH:3][C:4]([S:7]([O-:10])(=[O:8])=[O:9])=[CH:5][CH:6]=1.[OH:29][CH:26]([CH2:27][OH:28])[CH2:25][O:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[O:17][CH2:16][CH2:15][S+:14]([CH3:30])[CH3:13]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6645Methyl p-toluenesulfonateHCID 13386373HCID 13386373, compound

Product 1

HCID 20257053HCID 20257053, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A 7 g quantity of methyl p-toluenesulfonate was added to 2.58 g of 2-{2-(2,3-dihydroxypropoxy)phenoxy}ethyl methyl sulfide and 5 ml of methylene chloride and the mixture was stirred at room temperature for 24 hours. Ether was added to the reaction mixture. The oily product precipitated was separated and purified with ethanol-ether, affording 4.01 g of 2-{2-(2,3-dihydroxypropoxy)phenoxy}ethyldimethylsulfonium p-toluenesulfonate in 90.1% yield.

Workup

  1. customThe oily product precipitated
  2. customwas separated
  3. custompurified with ethanol-ether

Sources & evidence

ORD record
ord-7c8d8545c0ef4a818d48e748d75aa38b
Source dataset
uspto-grants-1985_12
Patent number
US04556737

Reaction notes

Loading…