Hydrogen Bromide → HCID 178454686, compound

HRID 637565Notes

Reaction equation

C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13]C)[NH:9][C:8](=[O:15])[N:7]=[C:6]2[CH3:16].C([O:19][C:20](=[O:24])[CH2:21][CH2:22][CH3:23])C.Br>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[OH:13])[NH:9][C:8](=[O:15])[N:7]=[C:6]2[CH3:16].[C:20]([OH:24])(=[O:19])[CH2:21][CH2:22][CH3:23]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 178454705HCID 178454705, compound

Product 1

HCID 178454686HCID 178454686, compoundYield 80%

Procedure

When 6,7-dimethoxy-4-methyl-2(1H)quinazolinone-1-butanoic acid ethyl ester is refluxed with excess 40% aqueous HBr for 24 hours the title compound is afforded in 80% yield, mp 288°-299° C.

Sources & evidence

ORD record: ord-cbf34caf6c244855a2895473c596c389
Source dataset: uspto-grants-1985_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04556739

Reaction notes

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